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| Mouse Sphingosine 1-phosphate receptor 5 (aa 1-400) |
| Edg8 Swiss Prot# | | Q91X56 |
| Edg8 Protein names | | Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8) (Endothelial differentiation G-protein-coupled receptor 8) (Lysophospholipid receptor B4) |
| Edg8 Gene names | | S1pr5 Edg8 Lpb4 |
| Organism | | Mouse |
| Edg8 Entry name | | S1PR5_MOUSE |
| Edg8 Codon optimized cDNA(gene) Clone |
| Edg8 Cat # | | RPX1287 |
| Tag | | Edg8 contains A 6x histidine tag |
| Edg8 Formulation | | Liquid |
| Edg8 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Edg8 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Edg8 Protein |
| Edg8 Cat # | | PX1287 |
| Edg8 Source | | recombinant |
| Edg8 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Edg8 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Edg8 Activity | | N/A |
| Tag | | Edg8 Contains A 6x histidine tag |
| Edg8 Formulation | | Liquid |
| Edg8 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Edg8 Products | | For pricing and availability Click Here >>> |
| Edg8 family | | G-protein coupled receptor 1 family |
| Edg8 Subcellular locations | | Cell membrane; Multi-pass membrane protein. |
| Edg8 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell. |
| Edg8 Sequence | | DDBJ | EMBL | GenBank |
| Edg8 3D structure | | ModBase |
| Edg8 interaction | | STRING |
| Edg8 Proteomic | | PRIDE |
| Edg8 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Edg8 Organism specific | | CTD | MGI |
| Edg8 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Edg8 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Edg8 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |