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Mouse Sphingosine 1-phosphate receptor 5 (aa 1-400)
Edg8 Swiss Prot#
Q91X56
Edg8 Protein names
Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8) (Endothelial differentiation G-protein-coupled receptor 8) (Lysophospholipid receptor B4)
Edg8 Gene names
S1pr5 Edg8 Lpb4
Organism
Mouse
Edg8 Entry name
S1PR5_MOUSE
Edg8 Codon optimized cDNA(gene) Clone
Edg8 Cat #
RPX1287
Tag
Edg8 contains A 6x histidine tag
Edg8 Formulation
Liquid
Edg8 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Edg8 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Edg8 Protein
Edg8 Cat #
PX1287
Edg8 Source
recombinant
Edg8 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Edg8 Purity
>90%, as determined by SDS-PAGE under reducing conditions
Edg8 Activity
N/A
Tag
Edg8 Contains A 6x histidine tag
Edg8 Formulation
Liquid
Edg8 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Edg8 family
G-protein coupled receptor 1 family
Edg8 Subcellular locations
Cell membrane; Multi-pass membrane protein.
Edg8 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway. The S1P-induced survival of mature oligodendrocytes is mediated through a pertussis toxin-sensitive, Akt-dependent pathway. S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. These effects depend on the developmental stage of the cell.
Edg8 Sequence
DDBJ EMBL GenBank
Edg8 3D structure
ModBase
Edg8 interaction
STRING
Edg8 Proteomic
PRIDE
Edg8 Genome annotation
Ensembl GeneID KEGG UCSC
Edg8 Organism specific
CTD MGI
Edg8 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Edg8 Gene expression
Bgee ArrayExpress Genevestigator
Edg8 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY