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Human Metastasis-suppressor KiSS-1 (aa 19-138)

PP5098 Swiss Prot#

Q15726

PP5098 Protein names

Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10]

PP5098 Gene names

KISS1 PP5098

Organism

Human

PP5098 Entry name

KISS1_HUMAN

PP5098 Codon optimized cDNA(gene) Clone

PP5098 Cat #

RPX0806

Tag

PP5098 contains A 6x histidine tag

PP5098 Formulation

Liquid

PP5098 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PP5098 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PP5098 Protein

PP5098 Cat #

PX0806

PP5098 Source

recombinant

PP5098 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PP5098 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PP5098 Activity

N/A

Tag

PP5098 Contains A 6x histidine tag

PP5098 Formulation

Liquid

PP5098 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PP5098 family

KISS1 family

PP5098 Subcellular locations

Secreted.

PP5098 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

PP5098 Sequence

DDBJ

EMBL

GenBank

PP5098 3D structure

ModBase

PP5098 interaction

STRING

PP5098 Proteomic

PRIDE

PP5098 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PP5098 Organism specific

CTD

MGI

PP5098 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PP5098 Gene expression

Bgee

ArrayExpress

Genevestigator

PP5098 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY