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Human G-protein coupled receptor 143 (aa 57-404)

OA1 Swiss Prot#

P51810

OA1 Protein names

G-protein coupled receptor 143 (Ocular albinism type 1 protein)

OA1 Gene names

GPR143 OA1

Organism

Human

OA1 Entry name

GP143_HUMAN

OA1 Codon optimized cDNA(gene) Clone

OA1 Cat #

RPX0738

Tag

OA1 contains A 6x histidine tag

OA1 Formulation

Liquid

OA1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

OA1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant OA1 Protein

OA1 Cat #

PX0738

OA1 Source

recombinant

OA1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

OA1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

OA1 Activity

N/A

Tag

OA1 Contains A 6x histidine tag

OA1 Formulation

Liquid

OA1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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OA1 family

G-protein coupled receptor OA family

OA1 Subcellular locations

Golgi apparatus. Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.

OA1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

OA1 Sequence

DDBJ

EMBL

GenBank

OA1 3D structure

ModBase

OA1 interaction

STRING

OA1 Proteomic

PRIDE

OA1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

OA1 Organism specific

CTD

MGI

OA1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

OA1 Gene expression

Bgee

ArrayExpress

Genevestigator

OA1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY