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Human Neuronal calcium sensor 1 (aa 1-190)

FLUP Swiss Prot#

P62166

FLUP Protein names

Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)

FLUP Gene names

NCS1 FLUP FREQ

Organism

Human

FLUP Entry name

NCS1_HUMAN

FLUP Codon optimized cDNA(gene) Clone

FLUP Cat #

RPX0737

Tag

FLUP contains A 6x histidine tag

FLUP Formulation

Liquid

FLUP Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

FLUP Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant FLUP Protein

FLUP Cat #

PX0737

FLUP Source

recombinant

FLUP Applications

Western Blot, SDS-Page or may be used for other applications determined by user

FLUP Purity

>90%, as determined by SDS-PAGE under reducing conditions

FLUP Activity

N/A

Tag

FLUP Contains A 6x histidine tag

FLUP Formulation

Liquid

FLUP Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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FLUP family

Recoverin family

FLUP Subcellular locations

Golgi apparatus > Golgi stack membrane; Peripheral membrane protein. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cytoplasm > perinuclear region. Cell membrane; Peripheral membrane protein.

FLUP FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).

FLUP Sequence

DDBJ

EMBL

GenBank

FLUP 3D structure

ModBase

FLUP interaction

STRING

FLUP Proteomic

PRIDE

FLUP Genome annotation

Ensembl

GeneID

KEGG

UCSC

FLUP Organism specific

CTD

MGI

FLUP Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

FLUP Gene expression

Bgee

ArrayExpress

Genevestigator

FLUP Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY