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Human Beta-arrestin-2 (aa 1-409)

ARB2 Swiss Prot#

P32121

ARB2 Protein names

Beta-arrestin-2 (Arrestin beta-2)

ARB2 Gene names

ARRB2 ARB2 ARR2

Organism

Human

ARB2 Entry name

ARRB2_HUMAN

ARB2 Codon optimized cDNA(gene) Clone

ARB2 Cat #

RPX0733

Tag

ARB2 contains A 6x histidine tag

ARB2 Formulation

Liquid

ARB2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ARB2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARB2 Protein

ARB2 Cat #

PX0733

ARB2 Source

recombinant

ARB2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ARB2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ARB2 Activity

N/A

Tag

ARB2 Contains A 6x histidine tag

ARB2 Formulation

Liquid

ARB2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ARB2 family

Arrestin family

ARB2 Subcellular locations

Cytoplasm. Nucleus. Cell membrane. Membrane > clathrin-coated pit. Cytoplasmic vesicle.

ARB2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN.

ARB2 Sequence

DDBJ

EMBL

GenBank

ARB2 3D structure

ModBase

ARB2 interaction

STRING

ARB2 Proteomic

PRIDE

ARB2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ARB2 Organism specific

CTD

MGI

ARB2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ARB2 Gene expression

Bgee

ArrayExpress

Genevestigator

ARB2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY