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Human Beta-arrestin-1 (aa 1-418)

ARR1 Swiss Prot#

P49407

ARR1 Protein names

Beta-arrestin-1 (Arrestin beta-1)

ARR1 Gene names

ARRB1 ARR1

Organism

Human

ARR1 Entry name

ARRB1_HUMAN

ARR1 Codon optimized cDNA(gene) Clone

ARR1 Cat #

RPX0732

Tag

ARR1 contains A 6x histidine tag

ARR1 Formulation

Liquid

ARR1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ARR1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARR1 Protein

ARR1 Cat #

PX0732

ARR1 Source

recombinant

ARR1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ARR1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ARR1 Activity

N/A

Tag

ARR1 Contains A 6x histidine tag

ARR1 Formulation

Liquid

ARR1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ARR1 family

Arrestin family

ARR1 Subcellular locations

Cytoplasm. Nucleus. Cell membrane. Membrane > clathrin-coated pit. Cell projection > pseudopodium. Cytoplasmic vesicle.

ARR1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Involved in internalization of P2RY4 and UTP-stimulated internalization of P2RY2. Involved in phopshorylation-dependent internalization of OPRD1 ands subsequent recycling. Involved in the degradation of cAMP by recruiting cAMP phosphodiesterases to ligand-activated receptors.

ARR1 Sequence

DDBJ

EMBL

GenBank

ARR1 3D structure

ModBase

ARR1 interaction

STRING

ARR1 Proteomic

PRIDE

ARR1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ARR1 Organism specific

CTD

MGI

ARR1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ARR1 Gene expression

Bgee

ArrayExpress

Genevestigator

ARR1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY