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Human RAC-alpha serine threonine-protein kinase (aa 1-480)

PKB Swiss Prot#

P31749

PKB Protein names

RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (Proto-oncogene c-Akt)

PKB Gene names

AKT1 PKB RAC

Organism

Human

PKB Entry name

AKT1_HUMAN

PKB Codon optimized cDNA(gene) Clone

PKB Cat #

RPX0731

Tag

PKB contains A 6x histidine tag

PKB Formulation

Liquid

PKB Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PKB Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PKB Protein

PKB Cat #

PX0731

PKB Source

recombinant

PKB Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PKB Purity

>90%, as determined by SDS-PAGE under reducing conditions

PKB Activity

N/A

Tag

PKB Contains A 6x histidine tag

PKB Formulation

Liquid

PKB Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PKB family

Protein kinase superfamily, AGC Ser/Thr protein kinase family, RAC subfamily

PKB Subcellular locations

Cytoplasm. Nucleus. Cell membrane.

PKB FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

PKB Sequence

DDBJ

EMBL

GenBank

PKB 3D structure

ModBase

PKB interaction

STRING

PKB Proteomic

PRIDE

PKB Genome annotation

Ensembl

GeneID

KEGG

UCSC

PKB Organism specific

CTD

MGI

PKB Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PKB Gene expression

Bgee

ArrayExpress

Genevestigator

PKB Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY