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Human KiSS-1 receptor (aa 61-398)

AXOR12 Swiss Prot#

Q969F8

AXOR12 Protein names

KiSS-1 receptor (KiSS-1R) (Kisspeptins receptor) (Metastin receptor) (G-protein coupled receptor 54) (Hypogonadotropin-1) (G-protein coupled receptor OT7T175) (hOT7T175)

AXOR12 Gene names

KISS1R AXOR12 GPR54

Organism

Human

AXOR12 Entry name

KISSR_HUMAN

AXOR12 Codon optimized cDNA(gene) Clone

AXOR12 Cat #

RPX0618

Tag

AXOR12 contains A 6x histidine tag

AXOR12 Formulation

Liquid

AXOR12 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AXOR12 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AXOR12 Protein

AXOR12 Cat #

PX0618

AXOR12 Source

recombinant

AXOR12 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AXOR12 Purity

>90%, as determined by SDS-PAGE under reducing conditions

AXOR12 Activity

N/A

Tag

AXOR12 Contains A 6x histidine tag

AXOR12 Formulation

Liquid

AXOR12 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AXOR12 family

G-protein coupled receptor 1 family

AXOR12 Subcellular locations

Cell membrane; Multi-pass membrane protein.

AXOR12 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Receptor for metastin (kisspeptin-54 or kp-54), a C-terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melanomas and in some breast carcinomas without affecting tumorigenicity. The metastasis suppressor properties may be mediated in part by cell cycle arrest and induction of apoptosis in malignant cells. The receptor is essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. The receptor is also probably involved in the regulation and fine-tuning of trophoblast invasion generated by the trophoblast itself. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

AXOR12 Sequence

DDBJ

EMBL

GenBank

AXOR12 3D structure

ModBase

AXOR12 interaction

STRING

AXOR12 Proteomic

PRIDE

AXOR12 Genome annotation

Ensembl

GeneID

KEGG

UCSC

AXOR12 Organism specific

CTD

MGI

AXOR12 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AXOR12 Gene expression

Bgee

ArrayExpress

Genevestigator

AXOR12 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY