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Human G-protein coupled receptor 109A (aa 1-363)

HM74A Swiss Prot#

Q8TDS4

HM74A Protein names

G-protein coupled receptor 109A (Niacin receptor 1) (Nicotinic acid receptor) (G-protein coupled receptor HM74A)

HM74A Gene names

GPR109A HM74A NIACR1

Organism

Human

HM74A Entry name

G109A_HUMAN

HM74A Codon optimized cDNA(gene) Clone

HM74A Cat #

RPX0546

Tag

HM74A contains A 6x histidine tag

HM74A Formulation

Liquid

HM74A Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HM74A Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HM74A Protein

HM74A Cat #

PX0546

HM74A Source

recombinant

HM74A Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HM74A Purity

>90%, as determined by SDS-PAGE under reducing conditions

HM74A Activity

N/A

Tag

HM74A Contains A 6x histidine tag

HM74A Formulation

Liquid

HM74A Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HM74A family

G-protein coupled receptor 1 family

HM74A Subcellular locations

Cell membrane; Multi-pass membrane protein.

HM74A FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.

HM74A Sequence

DDBJ

EMBL

GenBank

HM74A 3D structure

ModBase

HM74A interaction

STRING

HM74A Proteomic

PRIDE

HM74A Genome annotation

Ensembl

GeneID

KEGG

UCSC

HM74A Organism specific

CTD

MGI

HM74A Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HM74A Gene expression

Bgee

ArrayExpress

Genevestigator

HM74A Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY