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Human C-X-C chemokine receptor type 4 (aa 1-352)
CXCR4 Swiss Prot#
P61073
CXCR4 Protein names
C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (Fusin) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (LCR1) (FB22) (NPYRL) (HM89) (CD antigen CD184)
CXCR4 Gene names
CXCR4
Organism
Human
CXCR4 Entry name
CXCR4_HUMAN
CXCR4 Codon optimized cDNA(gene) Clone
CXCR4 Cat #
RPX0501
Tag
CXCR4 contains A 6x histidine tag
CXCR4 Formulation
Liquid
CXCR4 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
CXCR4 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant CXCR4 Protein
CXCR4 Cat #
PX0501
CXCR4 Source
recombinant
CXCR4 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
CXCR4 Purity
>90%, as determined by SDS-PAGE under reducing conditions
CXCR4 Activity
N/A
Tag
CXCR4 Contains A 6x histidine tag
CXCR4 Formulation
Liquid
CXCR4 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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CXCR4 family
G-protein coupled receptor 1 family
CXCR4 Subcellular locations
Cell membrane; Multi-pass membrane protein.
CXCR4 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ions levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhance intracellular calcium ions and reduce cellular cAMP levels. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
CXCR4 Sequence
DDBJ EMBL GenBank
CXCR4 3D structure
ModBase
CXCR4 interaction
STRING
CXCR4 Proteomic
PRIDE
CXCR4 Genome annotation
Ensembl GeneID KEGG UCSC
CXCR4 Organism specific
CTD MGI
CXCR4 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
CXCR4 Gene expression
Bgee ArrayExpress Genevestigator
CXCR4 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY