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| Human Lipid phosphate phosphohydrolase 1 (aa 23-284) |
| LPP1 Swiss Prot# | | O14494 |
| LPP1 Protein names | | Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a) |
| LPP1 Gene names | | PPAP2A LPP1 |
| Organism | | Human |
| LPP1 Entry name | | LPP1_HUMAN |
| LPP1 Codon optimized cDNA(gene) Clone |
| LPP1 Cat # | | RPX0009 |
| Tag | | LPP1 contains A 6x histidine tag |
| LPP1 Formulation | | Liquid |
| LPP1 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| LPP1 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant LPP1 Protein |
| LPP1 Cat # | | PX0009 |
| LPP1 Source | | recombinant |
| LPP1 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| LPP1 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| LPP1 Activity | | N/A |
| Tag | | LPP1 Contains A 6x histidine tag |
| LPP1 Formulation | | Liquid |
| LPP1 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant LPP1 Products | | For pricing and availability Click Here >>> |
| LPP1 family | | PA-phosphatase related phosphoesterase family |
| LPP1 Subcellular locations | | Cell membrane; Multi-pass membrane protein. |
| LPP1 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. |
| LPP1 Sequence | | DDBJ | EMBL | GenBank |
| LPP1 3D structure | | ModBase |
| LPP1 interaction | | STRING |
| LPP1 Proteomic | | PRIDE |
| LPP1 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| LPP1 Organism specific | | CTD | MGI |
| LPP1 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| LPP1 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| LPP1 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |