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Human Lipid phosphate phosphohydrolase 1 (aa 23-284)
LPP1 Swiss Prot#
O14494
LPP1 Protein names
Lipid phosphate phosphohydrolase 1 (EC 3.1.3.4) (Phosphatidic acid phosphatase 2a) (PAP-2a) (PAP2a) (PAP2-alpha) (Phosphatidate phosphohydrolase type 2a)
LPP1 Gene names
PPAP2A LPP1
Organism
Human
LPP1 Entry name
LPP1_HUMAN
LPP1 Codon optimized cDNA(gene) Clone
LPP1 Cat #
RPX0009
Tag
LPP1 contains A 6x histidine tag
LPP1 Formulation
Liquid
LPP1 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
LPP1 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant LPP1 Protein
LPP1 Cat #
PX0009
LPP1 Source
recombinant
LPP1 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
LPP1 Purity
>90%, as determined by SDS-PAGE under reducing conditions
LPP1 Activity
N/A
Tag
LPP1 Contains A 6x histidine tag
LPP1 Formulation
Liquid
LPP1 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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LPP1 family
PA-phosphatase related phosphoesterase family
LPP1 Subcellular locations
Cell membrane; Multi-pass membrane protein.
LPP1 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
LPP1 Sequence
DDBJ EMBL GenBank
LPP1 3D structure
ModBase
LPP1 interaction
STRING
LPP1 Proteomic
PRIDE
LPP1 Genome annotation
Ensembl GeneID KEGG UCSC
LPP1 Organism specific
CTD MGI
LPP1 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
LPP1 Gene expression
Bgee ArrayExpress Genevestigator
LPP1 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY