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Human Nuclear protein NP60 (aa 1-553)

HIBDL Swiss Prot#

Q49A26

HIBDL Protein names

Nuclear protein NP60 (Nuclear protein of 60 kDa) (3-hydroxyisobutyrate dehydrogenase-like protein) (Cytokine-like nuclear factor N-PAC)

HIBDL Gene names

NP60 (HIBDL)

Organism

Human

HIBDL Entry name

GLYR1_HUMAN

HIBDL Codon optimized cDNA(gene) Clone

HIBDL Cat #

RPR0607

Tag

HIBDL contains A 6x histidine tag

HIBDL Formulation

Liquid

HIBDL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

HIBDL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant HIBDL Protein

HIBDL Cat #

PR0607

HIBDL Source

recombinant

HIBDL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

HIBDL Purity

>90%, as determined by SDS-PAGE under reducing conditions

HIBDL Activity

N/A

Tag

HIBDL Contains A 6x histidine tag

HIBDL Formulation

Liquid

HIBDL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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HIBDL family

3-hydroxyisobutyrate dehydrogenase family, NP60 subfamily

HIBDL Subcellular locations

Nucleus.

HIBDL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).

HIBDL Sequence

DDBJ

EMBL

GenBank

HIBDL 3D structure

ModBase

HIBDL interaction

STRING

HIBDL Proteomic

PRIDE

HIBDL Genome annotation

Ensembl

GeneID

KEGG

UCSC

HIBDL Organism specific

CTD

MGI

HIBDL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

HIBDL Gene expression

Bgee

ArrayExpress

Genevestigator

HIBDL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY