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Human Polypyrimidine tract-binding protein 1 (aa 1-531)

PTB Swiss Prot#

P26599

PTB Protein names

Polypyrimidine tract-binding protein 1 (PTB) (Heterogeneous nuclear ribonucleoprotein I) (hnRNP I) (57 kDa RNA-binding protein PPTB-1)

PTB Gene names

PTBP1 (PTB)

Organism

Human

PTB Entry name

PTBP1_HUMAN

PTB Codon optimized cDNA(gene) Clone

PTB Cat #

RPR0595

Tag

PTB contains A 6x histidine tag

PTB Formulation

Liquid

PTB Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PTB Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PTB Protein

PTB Cat #

PR0595

PTB Source

recombinant

PTB Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PTB Purity

>90%, as determined by SDS-PAGE under reducing conditions

PTB Activity

N/A

Tag

PTB Contains A 6x histidine tag

PTB Formulation

Liquid

PTB Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PTB family

-

PTB Subcellular locations

Nucleus.

PTB FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA.

PTB Sequence

DDBJ

EMBL

GenBank

PTB 3D structure

ModBase

PTB interaction

STRING

PTB Proteomic

PRIDE

PTB Genome annotation

Ensembl

GeneID

KEGG

UCSC

PTB Organism specific

CTD

MGI

PTB Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PTB Gene expression

Bgee

ArrayExpress

Genevestigator

PTB Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY