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Human F-box-like WD repeat-containing TBL1XR1 (aa 1-514)

IRA1 Swiss Prot#

Q9BZK7

IRA1 Protein names

F-box-like/WD repeat-containing protein TBL1XR1 (Transducin beta-like 1X-related protein 1) (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1)

IRA1 Gene names

TBL1XR1 (IRA1) (TBLR1)

Organism

Human

IRA1 Entry name

TBL1R_HUMAN

IRA1 Codon optimized cDNA(gene) Clone

IRA1 Cat #

RPR0585

Tag

IRA1 contains A 6x histidine tag

IRA1 Formulation

Liquid

IRA1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

IRA1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant IRA1 Protein

IRA1 Cat #

PR0585

IRA1 Source

recombinant

IRA1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

IRA1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

IRA1 Activity

N/A

Tag

IRA1 Contains A 6x histidine tag

IRA1 Formulation

Liquid

IRA1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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IRA1 family

WD repeat EBI family

IRA1 Subcellular locations

Nucleus.

IRA1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

IRA1 Sequence

DDBJ

EMBL

GenBank

IRA1 3D structure

ModBase

IRA1 interaction

STRING

IRA1 Proteomic

PRIDE

IRA1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

IRA1 Organism specific

CTD

MGI

IRA1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

IRA1 Gene expression

Bgee

ArrayExpress

Genevestigator

IRA1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY