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| Human Nuclear-interacting partner ALK (aa 1-502) |
| NIPA Swiss Prot# | | Q86WB0 |
| NIPA Protein names | | Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1) |
| NIPA Gene names | | ZC3HC1 (NIPA) (HSPC216) |
| Organism | | Human |
| NIPA Entry name | | NIPA_HUMAN |
| NIPA Codon optimized cDNA(gene) Clone |
| NIPA Cat # | | RPR0580 |
| Tag | | NIPA contains A 6x histidine tag |
| NIPA Formulation | | Liquid |
| NIPA Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| NIPA Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant NIPA Protein |
| NIPA Cat # | | PR0580 |
| NIPA Source | | recombinant |
| NIPA Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| NIPA Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| NIPA Activity | | N/A |
| Tag | | NIPA Contains A 6x histidine tag |
| NIPA Formulation | | Liquid |
| NIPA Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant NIPA Products | | For pricing and availability Click Here >>> |
| NIPA family | | - |
| NIPA Subcellular locations | | Nucleus. |
| NIPA FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. |
| NIPA Sequence | | DDBJ | EMBL | GenBank |
| NIPA 3D structure | | ModBase |
| NIPA interaction | | STRING |
| NIPA Proteomic | | PRIDE |
| NIPA Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| NIPA Organism specific | | CTD | MGI |
| NIPA Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| NIPA Gene expression | | Bgee | ArrayExpress | Genevestigator |
| NIPA Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |