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Human Nuclear-interacting partner ALK (aa 1-502)
NIPA Swiss Prot#
Q86WB0
NIPA Protein names
Nuclear-interacting partner of ALK (Nuclear-interacting partner of anaplastic lymphoma kinase) (hNIPA) (Zinc finger C3HC-type protein 1)
NIPA Gene names
ZC3HC1 (NIPA) (HSPC216)
Organism
Human
NIPA Entry name
NIPA_HUMAN
NIPA Codon optimized cDNA(gene) Clone
NIPA Cat #
RPR0580
Tag
NIPA contains A 6x histidine tag
NIPA Formulation
Liquid
NIPA Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
NIPA Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant NIPA Protein
NIPA Cat #
PR0580
NIPA Source
recombinant
NIPA Applications
Western Blot, SDS-Page or may be used for other applications determined by user
NIPA Purity
>90%, as determined by SDS-PAGE under reducing conditions
NIPA Activity
N/A
Tag
NIPA Contains A 6x histidine tag
NIPA Formulation
Liquid
NIPA Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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NIPA family
-
NIPA Subcellular locations
Nucleus.
NIPA FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
NIPA Sequence
DDBJ EMBL GenBank
NIPA 3D structure
ModBase
NIPA interaction
STRING
NIPA Proteomic
PRIDE
NIPA Genome annotation
Ensembl GeneID KEGG UCSC
NIPA Organism specific
CTD MGI
NIPA Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
NIPA Gene expression
Bgee ArrayExpress Genevestigator
NIPA Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY