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Human Bile acid receptor (aa 1-486)

BAR Swiss Prot#

Q96RI1

BAR Protein names

Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14)

BAR Gene names

NR1H4 (BAR) (FXR) (HRR1) (RIP14)

Organism

Human

BAR Entry name

NR1H4_HUMAN

BAR Codon optimized cDNA(gene) Clone

BAR Cat #

RPR0570

Tag

BAR contains A 6x histidine tag

BAR Formulation

Liquid

BAR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BAR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BAR Protein

BAR Cat #

PR0570

BAR Source

recombinant

BAR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BAR Purity

>90%, as determined by SDS-PAGE under reducing conditions

BAR Activity

N/A

Tag

BAR Contains A 6x histidine tag

BAR Formulation

Liquid

BAR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BAR family

Nuclear hormone receptor family, NR1 subfamily

BAR Subcellular locations

Nucleus.

BAR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

BAR Sequence

DDBJ

EMBL

GenBank

BAR 3D structure

ModBase

BAR interaction

STRING

BAR Proteomic

PRIDE

BAR Genome annotation

Ensembl

GeneID

KEGG

UCSC

BAR Organism specific

CTD

MGI

BAR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BAR Gene expression

Bgee

ArrayExpress

Genevestigator

BAR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY