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Human CUG-BP- ETR-3-like factor 1 (aa 1-486)
BRUNOL2 Swiss Prot#
Q92879
BRUNOL2 Protein names
CUG-BP- and ETR-3-like factor 1 (CELF-1) (Bruno-like protein 2) (RNA-binding protein BRUNOL-2) (CUG triplet repeat RNA-binding protein 1) (CUG-BP1) (Deadenylation factor CUG-BP) (50 kDa nuclear polyadenylated RNA-binding protein) (Embryo deadenylation element-binding protein homolog) (EDEN-BP homolog)
BRUNOL2 Gene names
CUGBP1 (BRUNOL2) (CELF1) (CUGBP) (NAB50)
Organism
Human
BRUNOL2 Entry name
CELF1_HUMAN
BRUNOL2 Codon optimized cDNA(gene) Clone
BRUNOL2 Cat #
RPR0569
Tag
BRUNOL2 contains A 6x histidine tag
BRUNOL2 Formulation
Liquid
BRUNOL2 Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
BRUNOL2 Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant BRUNOL2 Protein
BRUNOL2 Cat #
PR0569
BRUNOL2 Source
recombinant
BRUNOL2 Applications
Western Blot, SDS-Page or may be used for other applications determined by user
BRUNOL2 Purity
>90%, as determined by SDS-PAGE under reducing conditions
BRUNOL2 Activity
N/A
Tag
BRUNOL2 Contains A 6x histidine tag
BRUNOL2 Formulation
Liquid
BRUNOL2 Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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BRUNOL2 family
CELF/BRUNOL family
BRUNOL2 Subcellular locations
Nucleus. Cytoplasm.
BRUNOL2 FUNCTION According to UniProtKB Swiss Prot
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.
BRUNOL2 Sequence
DDBJ EMBL GenBank
BRUNOL2 3D structure
ModBase
BRUNOL2 interaction
STRING
BRUNOL2 Proteomic
PRIDE
BRUNOL2 Genome annotation
Ensembl GeneID KEGG UCSC
BRUNOL2 Organism specific
CTD MGI
BRUNOL2 Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
BRUNOL2 Gene expression
Bgee ArrayExpress Genevestigator
BRUNOL2 Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY