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Human Programmed cell death protein 4 (aa 1-469)

H731 Swiss Prot#

Q53EL6

H731 Protein names

Programmed cell death protein 4 (Nuclear antigen H731-like) (Neoplastic transformation inhibitor protein) (Protein 197/15a)

H731 Gene names

PDCD4 (H731)

Organism

Human

H731 Entry name

PDCD4_HUMAN

H731 Codon optimized cDNA(gene) Clone

H731 Cat #

RPR0559

Tag

H731 contains A 6x histidine tag

H731 Formulation

Liquid

H731 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

H731 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant H731 Protein

H731 Cat #

PR0559

H731 Source

recombinant

H731 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

H731 Purity

>90%, as determined by SDS-PAGE under reducing conditions

H731 Activity

N/A

Tag

H731 Contains A 6x histidine tag

H731 Formulation

Liquid

H731 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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H731 family

PDCD4 family

H731 Subcellular locations

Nucleus. Cytoplasm.

H731 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

H731 Sequence

DDBJ

EMBL

GenBank

H731 3D structure

ModBase

H731 interaction

STRING

H731 Proteomic

PRIDE

H731 Genome annotation

Ensembl

GeneID

KEGG

UCSC

H731 Organism specific

CTD

MGI

H731 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

H731 Gene expression

Bgee

ArrayExpress

Genevestigator

H731 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY