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| Human Hepatocyte nuclear factor 3-beta (aa 1-457) |
| HNF3B Swiss Prot# | | Q9Y261 |
| HNF3B Protein names | | Hepatocyte nuclear factor 3-beta (HNF-3-beta) (HNF-3B) (Forkhead box protein A2) |
| HNF3B Gene names | | FOXA2 (HNF3B) (TCF3B) |
| Organism | | Human |
| HNF3B Entry name | | FOXA2_HUMAN |
| HNF3B Codon optimized cDNA(gene) Clone |
| HNF3B Cat # | | RPR0549 |
| Tag | | HNF3B contains A 6x histidine tag |
| HNF3B Formulation | | Liquid |
| HNF3B Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| HNF3B Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant HNF3B Protein |
| HNF3B Cat # | | PR0549 |
| HNF3B Source | | recombinant |
| HNF3B Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| HNF3B Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| HNF3B Activity | | N/A |
| Tag | | HNF3B Contains A 6x histidine tag |
| HNF3B Formulation | | Liquid |
| HNF3B Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant HNF3B Products | | For pricing and availability Click Here >>> |
| HNF3B family | | - |
| HNF3B Subcellular locations | | Nucleus. Cytoplasm. |
| HNF3B FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| HNF3B Sequence | | DDBJ | EMBL | GenBank |
| HNF3B 3D structure | | ModBase |
| HNF3B interaction | | STRING |
| HNF3B Proteomic | | PRIDE |
| HNF3B Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| HNF3B Organism specific | | CTD | MGI |
| HNF3B Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| HNF3B Gene expression | | Bgee | ArrayExpress | Genevestigator |
| HNF3B Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
