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| Human RuvB-like 1 (aa 1-456) |
| INO80H Swiss Prot# | | Q9Y265 |
| INO80H Protein names | | RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha) (INO80 complex subunit H) |
| INO80H Gene names | | RUVBL1 (INO80H) (NMP238) (TIP49) (TIP49A) |
| Organism | | Human |
| INO80H Entry name | | RUVB1_HUMAN |
| INO80H Codon optimized cDNA(gene) Clone |
| INO80H Cat # | | RPR0548 |
| Tag | | INO80H contains A 6x histidine tag |
| INO80H Formulation | | Liquid |
| INO80H Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| INO80H Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant INO80H Protein |
| INO80H Cat # | | PR0548 |
| INO80H Source | | recombinant |
| INO80H Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| INO80H Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| INO80H Activity | | N/A |
| Tag | | INO80H Contains A 6x histidine tag |
| INO80H Formulation | | Liquid |
| INO80H Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant INO80H Products | | For pricing and availability Click Here >>> |
| INO80H family | | RuvB family |
| INO80H Subcellular locations | | Nucleus matrix. Nucleus > nucleoplasm. Cytoplasm. Membrane. Cytoplasm > cytoskeleton > centrosome. |
| INO80H FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.; FUNCTION: May be able to bind plasminogen at cell surface and enhance plasminogen activation.; FUNCTION: Essential for cell proliferation. |
| INO80H Sequence | | DDBJ | EMBL | GenBank |
| INO80H 3D structure | | ModBase |
| INO80H interaction | | STRING |
| INO80H Proteomic | | PRIDE |
| INO80H Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| INO80H Organism specific | | CTD | MGI |
| INO80H Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| INO80H Gene expression | | Bgee | ArrayExpress | Genevestigator |
| INO80H Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
