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Human Oxysterols receptor LXR-alpha (aa 1-447)

LXRA Swiss Prot#

Q13133

LXRA Protein names

Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear orphan receptor LXR-alpha) (Nuclear receptor subfamily 1 group H member 3)

LXRA Gene names

NR1H3 (LXRA)

Organism

Human

LXRA Entry name

NR1H3_HUMAN

LXRA Codon optimized cDNA(gene) Clone

LXRA Cat #

RPR0538

Tag

LXRA contains A 6x histidine tag

LXRA Formulation

Liquid

LXRA Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

LXRA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant LXRA Protein

LXRA Cat #

PR0538

LXRA Source

recombinant

LXRA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

LXRA Purity

>90%, as determined by SDS-PAGE under reducing conditions

LXRA Activity

N/A

Tag

LXRA Contains A 6x histidine tag

LXRA Formulation

Liquid

LXRA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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LXRA family

Nuclear hormone receptor family, NR1 subfamily

LXRA Subcellular locations

Nucleus.

LXRA FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).

LXRA Sequence

DDBJ

EMBL

GenBank

LXRA 3D structure

ModBase

LXRA interaction

STRING

LXRA Proteomic

PRIDE

LXRA Genome annotation

Ensembl

GeneID

KEGG

UCSC

LXRA Organism specific

CTD

MGI

LXRA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

LXRA Gene expression

Bgee

ArrayExpress

Genevestigator

LXRA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY