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Human Eukaryotic initiation factor 4A-III (aa 2-411)

DDX48 Swiss Prot#

P38919

DDX48 Protein names

Eukaryotic initiation factor 4A-III (EC 3.6.1.-) (Eukaryotic translation initiation factor 4A isoform 3) (ATP-dependent RNA helicase eIF4A-3) (ATP-dependent RNA helicase DDX48) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265)

DDX48 Gene names

EIF4A3 (DDX48) (KIAA0111)

Organism

Human

DDX48 Entry name

IF4A3_HUMAN

DDX48 Codon optimized cDNA(gene) Clone

DDX48 Cat #

RPR0515

Tag

DDX48 contains A 6x histidine tag

DDX48 Formulation

Liquid

DDX48 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DDX48 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DDX48 Protein

DDX48 Cat #

PR0515

DDX48 Source

recombinant

DDX48 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DDX48 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DDX48 Activity

N/A

Tag

DDX48 Contains A 6x histidine tag

DDX48 Formulation

Liquid

DDX48 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DDX48 family

DEAD box helicase family, eIF4A subfamily

DDX48 Subcellular locations

Nucleus. Nucleus speckle. Cytoplasm.

DDX48 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: ATP-dependent RNA helicase. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Constitutes at least part of the platform anchoring other EJC proteins to spliced mRNAs. Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH/RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH/RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed.

DDX48 Sequence

DDBJ

EMBL

GenBank

DDX48 3D structure

ModBase

DDX48 interaction

STRING

DDX48 Proteomic

PRIDE

DDX48 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DDX48 Organism specific

CTD

MGI

DDX48 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DDX48 Gene expression

Bgee

ArrayExpress

Genevestigator

DDX48 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY