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| Human Phosphorylated adapter RNA export protein (aa 1-394) |
| RNUXA Swiss Prot# | | Q9H814 |
| RNUXA Protein names | | Phosphorylated adapter RNA export protein (RNA U small nuclear RNA export adapter protein) |
| RNUXA Gene names | | PHAX (RNUXA) |
| Organism | | Human |
| RNUXA Entry name | | PHAX_HUMAN |
| RNUXA Codon optimized cDNA(gene) Clone |
| RNUXA Cat # | | RPR0505 |
| Tag | | RNUXA contains A 6x histidine tag |
| RNUXA Formulation | | Liquid |
| RNUXA Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| RNUXA Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant RNUXA Protein |
| RNUXA Cat # | | PR0505 |
| RNUXA Source | | recombinant |
| RNUXA Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| RNUXA Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| RNUXA Activity | | N/A |
| Tag | | RNUXA Contains A 6x histidine tag |
| RNUXA Formulation | | Liquid |
| RNUXA Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant RNUXA Products | | For pricing and availability Click Here >>> |
| RNUXA family | | PHAX family |
| RNUXA Subcellular locations | | Nucleus > nucleoplasm. Nucleus > Cajal body. Cytoplasm. |
| RNUXA FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. |
| RNUXA Sequence | | DDBJ | EMBL | GenBank |
| RNUXA 3D structure | | ModBase |
| RNUXA interaction | | STRING |
| RNUXA Proteomic | | PRIDE |
| RNUXA Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| RNUXA Organism specific | | CTD | MGI |
| RNUXA Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| RNUXA Gene expression | | Bgee | ArrayExpress | Genevestigator |
| RNUXA Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
