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| Human Protein arginine N-methyltransferase 6 (aa 1-375) |
| HRMT1L6 Swiss Prot# | | Q96LA8 |
| HRMT1L6 Protein names | | Protein arginine N-methyltransferase 6 (EC 2.1.1.-) (Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6) |
| HRMT1L6 Gene names | | PRMT6 (HRMT1L6) |
| Organism | | Human |
| HRMT1L6 Entry name | | ANM6_HUMAN |
| HRMT1L6 Codon optimized cDNA(gene) Clone |
| HRMT1L6 Cat # | | RPR0497 |
| Tag | | HRMT1L6 contains A 6x histidine tag |
| HRMT1L6 Formulation | | Liquid |
| HRMT1L6 Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| HRMT1L6 Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant HRMT1L6 Protein |
| HRMT1L6 Cat # | | PR0497 |
| HRMT1L6 Source | | recombinant |
| HRMT1L6 Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| HRMT1L6 Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| HRMT1L6 Activity | | N/A |
| Tag | | HRMT1L6 Contains A 6x histidine tag |
| HRMT1L6 Formulation | | Liquid |
| HRMT1L6 Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant HRMT1L6 Products | | For pricing and availability Click Here >>> |
| HRMT1L6 family | | Protein arginine N-methyltransferase family, PRMT6 subfamily |
| HRMT1L6 Subcellular locations | | Nucleus. |
| HRMT1L6 FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). It thereby acts as a transcription corepressor of various genes such as HOXA2. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to stimulate the polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC). |
| HRMT1L6 Sequence | | DDBJ | EMBL | GenBank |
| HRMT1L6 3D structure | | ModBase |
| HRMT1L6 interaction | | STRING |
| HRMT1L6 Proteomic | | PRIDE |
| HRMT1L6 Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| HRMT1L6 Organism specific | | CTD | MGI |
| HRMT1L6 Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| HRMT1L6 Gene expression | | Bgee | ArrayExpress | Genevestigator |
| HRMT1L6 Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |
