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Human Heterogeneous nuclear ribonucleoprotein D0 (aa 1-355)

AUF1 Swiss Prot#

Q14103

AUF1 Protein names

Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)

AUF1 Gene names

HNRNPD (AUF1) (HNRPD)

Organism

Human

AUF1 Entry name

HNRPD_HUMAN

AUF1 Codon optimized cDNA(gene) Clone

AUF1 Cat #

RPR0482

Tag

AUF1 contains A 6x histidine tag

AUF1 Formulation

Liquid

AUF1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

AUF1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant AUF1 Protein

AUF1 Cat #

PR0482

AUF1 Source

recombinant

AUF1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

AUF1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

AUF1 Activity

N/A

Tag

AUF1 Contains A 6x histidine tag

AUF1 Formulation

Liquid

AUF1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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AUF1 family

-

AUF1 Subcellular locations

Nucleus. Cytoplasm.

AUF1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain.

AUF1 Sequence

DDBJ

EMBL

GenBank

AUF1 3D structure

ModBase

AUF1 interaction

STRING

AUF1 Proteomic

PRIDE

AUF1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

AUF1 Organism specific

CTD

MGI

AUF1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

AUF1 Gene expression

Bgee

ArrayExpress

Genevestigator

AUF1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY