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Human Nuclear inhibitor protein phosphatase 1 (aa 1-351)

ARD1 Swiss Prot#

Q12972

ARD1 Protein names

Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]

ARD1 Gene names

PPP1R8 (ARD1) (NIPP1)

Organism

Human

ARD1 Entry name

PP1R8_HUMAN

ARD1 Codon optimized cDNA(gene) Clone

ARD1 Cat #

RPR0479

Tag

ARD1 contains A 6x histidine tag

ARD1 Formulation

Liquid

ARD1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

ARD1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant ARD1 Protein

ARD1 Cat #

PR0479

ARD1 Source

recombinant

ARD1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

ARD1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

ARD1 Activity

N/A

Tag

ARD1 Contains A 6x histidine tag

ARD1 Formulation

Liquid

ARD1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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ARD1 family

-

ARD1 Subcellular locations

Nucleus. Nucleus speckle. Cytoplasm.

ARD1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.; FUNCTION: Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.

ARD1 Sequence

DDBJ

EMBL

GenBank

ARD1 3D structure

ModBase

ARD1 interaction

STRING

ARD1 Proteomic

PRIDE

ARD1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

ARD1 Organism specific

CTD

MGI

ARD1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

ARD1 Gene expression

Bgee

ArrayExpress

Genevestigator

ARD1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY