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Human Nuclear distribution protein nudE-like 1 (aa 1-345)

EOPA Swiss Prot#

Q9GZM8

EOPA Protein names

Nuclear distribution protein nudE-like 1 (Protein Nudel) (Mitosin-associated protein 1)

EOPA Gene names

NDEL1 (EOPA) (MITAP1) (NUDEL)

Organism

Human

EOPA Entry name

NDEL1_HUMAN

EOPA Codon optimized cDNA(gene) Clone

EOPA Cat #

RPR0474

Tag

EOPA contains A 6x histidine tag

EOPA Formulation

Liquid

EOPA Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

EOPA Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant EOPA Protein

EOPA Cat #

PR0474

EOPA Source

recombinant

EOPA Applications

Western Blot, SDS-Page or may be used for other applications determined by user

EOPA Purity

>90%, as determined by SDS-PAGE under reducing conditions

EOPA Activity

N/A

Tag

EOPA Contains A 6x histidine tag

EOPA Formulation

Liquid

EOPA Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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EOPA family

NudE family

EOPA Subcellular locations

Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Cytoplasm > cytoskeleton > spindle.

EOPA FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL.

EOPA Sequence

DDBJ

EMBL

GenBank

EOPA 3D structure

ModBase

EOPA interaction

STRING

EOPA Proteomic

PRIDE

EOPA Genome annotation

Ensembl

GeneID

KEGG

UCSC

EOPA Organism specific

CTD

MGI

EOPA Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

EOPA Gene expression

Bgee

ArrayExpress

Genevestigator

EOPA Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY