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Human Polyadenylate-binding protein 2 (aa 2-306)

PAB2 Swiss Prot#

Q86U42

PAB2 Protein names

Polyadenylate-binding protein 2 (Poly(A)-binding protein 2) (Poly(A)-binding protein II) (PABII) (Polyadenylate-binding nuclear protein 1) (Nuclear poly(A)-binding protein 1)

PAB2 Gene names

PABPN1 (PAB2) (PABP2)

Organism

Human

PAB2 Entry name

PABP2_HUMAN

PAB2 Codon optimized cDNA(gene) Clone

PAB2 Cat #

RPR0451

Tag

PAB2 contains A 6x histidine tag

PAB2 Formulation

Liquid

PAB2 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PAB2 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PAB2 Protein

PAB2 Cat #

PR0451

PAB2 Source

recombinant

PAB2 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PAB2 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PAB2 Activity

N/A

Tag

PAB2 Contains A 6x histidine tag

PAB2 Formulation

Liquid

PAB2 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PAB2 family

-

PAB2 Subcellular locations

Nucleus. Cytoplasm.

PAB2 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity).

PAB2 Sequence

DDBJ

EMBL

GenBank

PAB2 3D structure

ModBase

PAB2 interaction

STRING

PAB2 Proteomic

PRIDE

PAB2 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PAB2 Organism specific

CTD

MGI

PAB2 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PAB2 Gene expression

Bgee

ArrayExpress

Genevestigator

PAB2 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY