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Human Proteasome activator complex subunit 3 (aa 1-254)

PSME3 Swiss Prot#

P61289

PSME3 Protein names

Proteasome activator complex subunit 3 (Proteasome activator 28 subunit gamma) (PA28gamma) (PA28g) (Activator of multicatalytic protease subunit 3) (11S regulator complex subunit gamma) (REG-gamma) (Ki nuclear autoantigen)

PSME3 Gene names

PSME3

Organism

Human

PSME3 Entry name

PSME3_HUMAN

PSME3 Codon optimized cDNA(gene) Clone

PSME3 Cat #

RPR0416

Tag

PSME3 contains A 6x histidine tag

PSME3 Formulation

Liquid

PSME3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PSME3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PSME3 Protein

PSME3 Cat #

PR0416

PSME3 Source

recombinant

PSME3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PSME3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PSME3 Activity

N/A

Tag

PSME3 Contains A 6x histidine tag

PSME3 Formulation

Liquid

PSME3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PSME3 family

PA28 family

PSME3 Subcellular locations

Nucleus. Cytoplasm.

PSME3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

PSME3 Sequence

DDBJ

EMBL

GenBank

PSME3 3D structure

ModBase

PSME3 interaction

STRING

PSME3 Proteomic

PRIDE

PSME3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PSME3 Organism specific

CTD

MGI

PSME3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PSME3 Gene expression

Bgee

ArrayExpress

Genevestigator

PSME3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY