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Human Centromere protein R (aa 1-177)

CENPR Swiss Prot#

Q13352

CENPR Protein names

Centromere protein R (CENP-R) (Nuclear receptor-interacting factor 3) (Integrin beta-3-binding protein) (Beta3-endonexin)

CENPR Gene names

ITGB3BP (CENPR) (NRIF3)

Organism

Human

CENPR Entry name

CENPR_HUMAN

CENPR Codon optimized cDNA(gene) Clone

CENPR Cat #

RPR0373

Tag

CENPR contains A 6x histidine tag

CENPR Formulation

Liquid

CENPR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CENPR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CENPR Protein

CENPR Cat #

PR0373

CENPR Source

recombinant

CENPR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CENPR Purity

>90%, as determined by SDS-PAGE under reducing conditions

CENPR Activity

N/A

Tag

CENPR Contains A 6x histidine tag

CENPR Formulation

Liquid

CENPR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CENPR family

-

CENPR Subcellular locations

Nucleus. Chromosome > centromere. Nucleus. Nucleus. Cytoplasm. Cytoplasm.

CENPR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

CENPR Sequence

DDBJ

EMBL

GenBank

CENPR 3D structure

ModBase

CENPR interaction

STRING

CENPR Proteomic

PRIDE

CENPR Genome annotation

Ensembl

GeneID

KEGG

UCSC

CENPR Organism specific

CTD

MGI

CENPR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CENPR Gene expression

Bgee

ArrayExpress

Genevestigator

CENPR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY