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Human Nuclear cap-binding protein subunit 2 (aa 1-156)

CBP20 Swiss Prot#

P52298

CBP20 Protein names

Nuclear cap-binding protein subunit 2 (20 kDa nuclear cap-binding protein) (NCBP 20 kDa subunit) (CBP20) (NCBP-interacting protein 1) (NIP1) (Cell proliferation-inducing gene 55 protein)

CBP20 Gene names

NCBP2 (CBP20) (PIG55)

Organism

Human

CBP20 Entry name

NCBP2_HUMAN

CBP20 Codon optimized cDNA(gene) Clone

CBP20 Cat #

RPR0363

Tag

CBP20 contains A 6x histidine tag

CBP20 Formulation

Liquid

CBP20 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CBP20 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CBP20 Protein

CBP20 Cat #

PR0363

CBP20 Source

recombinant

CBP20 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CBP20 Purity

>90%, as determined by SDS-PAGE under reducing conditions

CBP20 Activity

N/A

Tag

CBP20 Contains A 6x histidine tag

CBP20 Formulation

Liquid

CBP20 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CBP20 family

RRM NCBP2 family

CBP20 Subcellular locations

Nucleus. Cytoplasm.

CBP20 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.

CBP20 Sequence

DDBJ

EMBL

GenBank

CBP20 3D structure

ModBase

CBP20 interaction

STRING

CBP20 Proteomic

PRIDE

CBP20 Genome annotation

Ensembl

GeneID

KEGG

UCSC

CBP20 Organism specific

CTD

MGI

CBP20 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CBP20 Gene expression

Bgee

ArrayExpress

Genevestigator

CBP20 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY