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Rat Catechol O-methyltransferase (aa 1-264)

Comt Swiss Prot#

P22734

Comt Protein names

Catechol O-methyltransferase (EC 2.1.1.6)

Comt Gene names

Comt

Organism

Rat

Comt Entry name

COMT_RAT

Comt Codon optimized cDNA(gene) Clone

Comt Cat #

RPR0282

Tag

Comt contains A 6x histidine tag

Comt Formulation

Liquid

Comt Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Comt Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Comt Protein

Comt Cat #

PR0282

Comt Source

recombinant

Comt Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Comt Purity

>90%, as determined by SDS-PAGE under reducing conditions

Comt Activity

N/A

Tag

Comt Contains A 6x histidine tag

Comt Formulation

Liquid

Comt Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Comt family

Methyltransferase superfamily, Catechol-O-methyltransferase family

Comt Subcellular locations

Cytoplasm. Cell membrane; Single-pass type II membrane protein; Extracellular side.

Comt FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Comt Sequence

DDBJ

EMBL

GenBank

Comt 3D structure

ModBase

Comt interaction

STRING

Comt Proteomic

PRIDE

Comt Genome annotation

Ensembl

GeneID

KEGG

UCSC

Comt Organism specific

CTD

MGI

Comt Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Comt Gene expression

Bgee

ArrayExpress

Genevestigator

Comt Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY