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Mouse Caspase-8 (aa 1-480)

Casp8 Swiss Prot#

O89110

Casp8 Protein names

Caspase-8 (CASP-8) (EC 3.4.22.61) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]

Casp8 Gene names

Casp8

Organism

Mouse

Casp8 Entry name

CASP8_MOUSE

Casp8 Codon optimized cDNA(gene) Clone

Casp8 Cat #

RPR0205

Tag

Casp8 contains A 6x histidine tag

Casp8 Formulation

Liquid

Casp8 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Casp8 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Casp8 Protein

Casp8 Cat #

PR0205

Casp8 Source

recombinant

Casp8 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Casp8 Purity

>90%, as determined by SDS-PAGE under reducing conditions

Casp8 Activity

N/A

Tag

Casp8 Contains A 6x histidine tag

Casp8 Formulation

Liquid

Casp8 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Casp8 family

Peptidase C14A family

Casp8 Subcellular locations

-

Casp8 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.

Casp8 Sequence

DDBJ

EMBL

GenBank

Casp8 3D structure

ModBase

Casp8 interaction

STRING

Casp8 Proteomic

PRIDE

Casp8 Genome annotation

Ensembl

GeneID

KEGG

UCSC

Casp8 Organism specific

CTD

MGI

Casp8 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Casp8 Gene expression

Bgee

ArrayExpress

Genevestigator

Casp8 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY