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Mouse Nuclear receptor subfamily 1 group I member 2 (aa 1-431)

Pxr Swiss Prot#

O54915

Pxr Protein names

Nuclear receptor subfamily 1 group I member 2 (Pregnane X receptor) (Orphan nuclear receptor PXR)

Pxr Gene names

Nr1i2 (Pxr)

Organism

Mouse

Pxr Entry name

NR1I2_MOUSE

Pxr Codon optimized cDNA(gene) Clone

Pxr Cat #

RPR0197

Tag

Pxr contains A 6x histidine tag

Pxr Formulation

Liquid

Pxr Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Pxr Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Pxr Protein

Pxr Cat #

PR0197

Pxr Source

recombinant

Pxr Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Pxr Purity

>90%, as determined by SDS-PAGE under reducing conditions

Pxr Activity

N/A

Tag

Pxr Contains A 6x histidine tag

Pxr Formulation

Liquid

Pxr Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Pxr family

Nuclear hormone receptor family, NR1 subfamily

Pxr Subcellular locations

Nucleus.

Pxr FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN).

Pxr Sequence

DDBJ

EMBL

GenBank

Pxr 3D structure

ModBase

Pxr interaction

STRING

Pxr Proteomic

PRIDE

Pxr Genome annotation

Ensembl

GeneID

KEGG

UCSC

Pxr Organism specific

CTD

MGI

Pxr Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Pxr Gene expression

Bgee

ArrayExpress

Genevestigator

Pxr Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY