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Human Cyclin-C (aa 1-283)

CCNC Swiss Prot#

P24863

CCNC Protein names

Cyclin-C (hSRB11)

CCNC Gene names

CCNC

Organism

Human

CCNC Entry name

CCNC_HUMAN

CCNC Codon optimized cDNA(gene) Clone

CCNC Cat #

RPR0043

Tag

CCNC contains A 6x histidine tag

CCNC Formulation

Liquid

CCNC Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

CCNC Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant CCNC Protein

CCNC Cat #

PR0043

CCNC Source

recombinant

CCNC Applications

Western Blot, SDS-Page or may be used for other applications determined by user

CCNC Purity

>90%, as determined by SDS-PAGE under reducing conditions

CCNC Activity

N/A

Tag

CCNC Contains A 6x histidine tag

CCNC Formulation

Liquid

CCNC Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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CCNC family

Cyclin family, Cyclin C subfamily

CCNC Subcellular locations

Nucleus.

CCNC FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

CCNC Sequence

DDBJ

EMBL

GenBank

CCNC 3D structure

ModBase

CCNC interaction

STRING

CCNC Proteomic

PRIDE

CCNC Genome annotation

Ensembl

GeneID

KEGG

UCSC

CCNC Organism specific

CTD

MGI

CCNC Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

CCNC Gene expression

Bgee

ArrayExpress

Genevestigator

CCNC Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY