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Mouse Centromere-associated protein E (aa 1-2474 )
Cenpe Swiss Prot#
Q6RT24
Cenpe Protein names
Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin superfamily protein 10) (KIF10) (Motor domain of KIF10)
Cenpe Gene names
Cenpe
Organism
Mus musculus (Mouse)
Cenpe Entry name
CENPE_MOUSE
Cenpe Codon optimized cDNA(gene) Clone
Cenpe Cat #
RPY2754
Tag
Cenpe contains A 6x histidine tag
Cenpe Formulation
Liquid
Cenpe Storage
Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
Cenpe Applications
Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.
Recombinant Cenpe Protein
Cenpe Cat #
PY2754
Cenpe Source
recombinant
Cenpe Applications
Western Blot, SDS-Page or may be used for other applications determined by user
Cenpe Purity
>90%, as determined by SDS-PAGE under reducing conditions
Cenpe Activity
N/A
Tag
Cenpe Contains A 6x histidine tag
Cenpe Formulation
Liquid
Cenpe Storage
;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.
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Cenpe family
Kinesin-like protein family
Cenpe Subcellular locations
Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore.
Cenpe FUNCTION According to UniProtKB Swiss Prot
FUNCTION: Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.
Cenpe Sequence
DDBJ EMBL GenBank
Cenpe 3D structure
ModBase
Cenpe interaction
STRING
Cenpe Proteomic
PRIDE
Cenpe Genome annotation
Ensembl GeneID KEGG UCSC
Cenpe Organism specific
CTD MGI
Cenpe Phylogenomics
eggNOG GeneTree HOGENOM HOVERGEN

InParanoid OrthoDB PhylomeDB OMA
Cenpe Gene expression
Bgee ArrayExpress Genevestigator
Cenpe Family and domain
InterPro PROSITE ProtoNet
FOR in vitro RESEARCH USE ONLY