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| Mouse Centromere-associated protein E (aa 1-2474 ) |
| Cenpe Swiss Prot# | | Q6RT24 |
| Cenpe Protein names | | Centromere-associated protein E (Centromere protein E) (CENP-E) (Kinesin superfamily protein 10) (KIF10) (Motor domain of KIF10) |
| Cenpe Gene names | | Cenpe |
| Organism | | Mus musculus (Mouse) |
| Cenpe Entry name | | CENPE_MOUSE |
| Cenpe Codon optimized cDNA(gene) Clone |
| Cenpe Cat # | | RPY2754 |
| Tag | | Cenpe contains A 6x histidine tag |
| Cenpe Formulation | | Liquid |
| Cenpe Storage | | Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Cenpe Applications | | Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function. |
| Recombinant Cenpe Protein |
| Cenpe Cat # | | PY2754 |
| Cenpe Source | | recombinant |
| Cenpe Applications | | Western Blot, SDS-Page or may be used for other applications determined by user |
| Cenpe Purity | | >90%, as determined by SDS-PAGE under reducing conditions |
| Cenpe Activity | | N/A |
| Tag | | Cenpe Contains A 6x histidine tag |
| Cenpe Formulation | | Liquid |
| Cenpe Storage | | ;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles. |
| Place Order for Recombinant Cenpe Products | | For pricing and availability Click Here >>> |
| Cenpe family | | Kinesin-like protein family |
| Cenpe Subcellular locations | | Cytoplasm > cytoskeleton > spindle. Chromosome > centromere > kinetochore. |
| Cenpe FUNCTION According to UniProtKB Swiss Prot | | FUNCTION: Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle. |
| Cenpe Sequence | | DDBJ | EMBL | GenBank |
| Cenpe 3D structure | | ModBase |
| Cenpe interaction | | STRING |
| Cenpe Proteomic | | PRIDE |
| Cenpe Genome annotation | | Ensembl | GeneID | KEGG | UCSC |
| Cenpe Organism specific | | CTD | MGI |
| Cenpe Phylogenomics | | eggNOG | GeneTree | HOGENOM | HOVERGEN |
| | InParanoid | OrthoDB | PhylomeDB | OMA |
| Cenpe Gene expression | | Bgee | ArrayExpress | Genevestigator |
| Cenpe Family and domain | | InterPro | PROSITE | ProtoNet |
| FOR in vitro RESEARCH USE ONLY |