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Human Telomere-associated protein RIF1 (aa 1-2472 )

RIF1 Swiss Prot#

Q5UIP0

RIF1 Protein names

Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)

RIF1 Gene names

RIF1

Organism

Homo sapiens (Human)

RIF1 Entry name

RIF1_HUMAN

RIF1 Codon optimized cDNA(gene) Clone

RIF1 Cat #

RPY2749

Tag

RIF1 contains A 6x histidine tag

RIF1 Formulation

Liquid

RIF1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RIF1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RIF1 Protein

RIF1 Cat #

PY2749

RIF1 Source

recombinant

RIF1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RIF1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

RIF1 Activity

N/A

Tag

RIF1 Contains A 6x histidine tag

RIF1 Formulation

Liquid

RIF1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RIF1 family

-

RIF1 Subcellular locations

Nucleus. Chromosome > telomere. Cytoplasm > cytoskeleton > spindle.

RIF1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S-phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints.

RIF1 Sequence

DDBJ

EMBL

GenBank

RIF1 3D structure

ModBase

RIF1 interaction

STRING

RIF1 Proteomic

PRIDE

RIF1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

RIF1 Organism specific

CTD

MGI

RIF1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RIF1 Gene expression

Bgee

ArrayExpress

Genevestigator

RIF1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY