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Human 1-phosphatidylinositol-4 5-bisphosphate phosphodiesterase (aa 1-2302 )

PLCE1 Swiss Prot#

Q9P212

PLCE1 Protein names

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)

PLCE1 Gene names

PLCE1 KIAA1516 PLCE PPLC

Organism

Homo sapiens (Human)

PLCE1 Entry name

PLCE1_HUMAN

PLCE1 Codon optimized cDNA(gene) Clone

PLCE1 Cat #

RPY2721

Tag

PLCE1 contains A 6x histidine tag

PLCE1 Formulation

Liquid

PLCE1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

PLCE1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant PLCE1 Protein

PLCE1 Cat #

PY2721

PLCE1 Source

recombinant

PLCE1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

PLCE1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

PLCE1 Activity

N/A

Tag

PLCE1 Contains A 6x histidine tag

PLCE1 Formulation

Liquid

PLCE1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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PLCE1 family

-

PLCE1 Subcellular locations

Cytoplasm > cytosol. Cell membrane. Golgi apparatus membrane.

PLCE1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.

PLCE1 Sequence

DDBJ

EMBL

GenBank

PLCE1 3D structure

ModBase

PLCE1 interaction

STRING

PLCE1 Proteomic

PRIDE

PLCE1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

PLCE1 Organism specific

CTD

MGI

PLCE1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

PLCE1 Gene expression

Bgee

ArrayExpress

Genevestigator

PLCE1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY