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Human Supervillin (aa 1-2214 )

SVIL Swiss Prot#

O95425

SVIL Protein names

Supervillin (Archvillin) (p205/p250)

SVIL Gene names

SVIL

Organism

Homo sapiens (Human)

SVIL Entry name

SVIL_HUMAN

SVIL Codon optimized cDNA(gene) Clone

SVIL Cat #

RPY2716

Tag

SVIL contains A 6x histidine tag

SVIL Formulation

Liquid

SVIL Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SVIL Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SVIL Protein

SVIL Cat #

PY2716

SVIL Source

recombinant

SVIL Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SVIL Purity

>90%, as determined by SDS-PAGE under reducing conditions

SVIL Activity

N/A

Tag

SVIL Contains A 6x histidine tag

SVIL Formulation

Liquid

SVIL Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SVIL family

Villin/gelsolin family

SVIL Subcellular locations

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm > cytoskeleton. Cell projection > invadopodium. Cell projection > podosome.

SVIL FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity).

SVIL Sequence

DDBJ

EMBL

GenBank

SVIL 3D structure

ModBase

SVIL interaction

STRING

SVIL Proteomic

PRIDE

SVIL Genome annotation

Ensembl

GeneID

KEGG

UCSC

SVIL Organism specific

CTD

MGI

SVIL Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SVIL Gene expression

Bgee

ArrayExpress

Genevestigator

SVIL Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY