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Mouse Rho GTPase-activating protein 32 (aa 1-2089 )

Grit Swiss Prot#

Q811P8

Grit Protein names

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Grit Gene names

Arhgap32 Grit Kiaa0712 Rics

Organism

Mus musculus (Mouse)

Grit Entry name

RHG32_MOUSE

Grit Codon optimized cDNA(gene) Clone

Grit Cat #

RPY2695

Tag

Grit contains A 6x histidine tag

Grit Formulation

Liquid

Grit Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Grit Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Grit Protein

Grit Cat #

PY2695

Grit Source

recombinant

Grit Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Grit Purity

>90%, as determined by SDS-PAGE under reducing conditions

Grit Activity

N/A

Tag

Grit Contains A 6x histidine tag

Grit Formulation

Liquid

Grit Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Grit family

PX domain-containing GAP family

Grit Subcellular locations

Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Cytoplasm > cell cortex. Endosome membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane. Membrane.

Grit FUNCTION According to UniProtKB Swiss Prot

FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.

Grit Sequence

DDBJ

EMBL

GenBank

Grit 3D structure

ModBase

Grit interaction

STRING

Grit Proteomic

PRIDE

Grit Genome annotation

Ensembl

GeneID

KEGG

UCSC

Grit Organism specific

CTD

MGI

Grit Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Grit Gene expression

Bgee

ArrayExpress

Genevestigator

Grit Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY