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Human Dedicator cytokinesis protein 3 (aa 1-2030 )

DOCK3 Swiss Prot#

Q8IZD9

DOCK3 Protein names

Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)

DOCK3 Gene names

DOCK3 KIAA0299 MOCA

Organism

Homo sapiens (Human)

DOCK3 Entry name

DOCK3_HUMAN

DOCK3 Codon optimized cDNA(gene) Clone

DOCK3 Cat #

RPY2684

Tag

DOCK3 contains A 6x histidine tag

DOCK3 Formulation

Liquid

DOCK3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

DOCK3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant DOCK3 Protein

DOCK3 Cat #

PY2684

DOCK3 Source

recombinant

DOCK3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

DOCK3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

DOCK3 Activity

N/A

Tag

DOCK3 Contains A 6x histidine tag

DOCK3 Formulation

Liquid

DOCK3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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DOCK3 family

DOCK family

DOCK3 Subcellular locations

Cytoplasm.

DOCK3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity).

DOCK3 Sequence

DDBJ

EMBL

GenBank

DOCK3 3D structure

ModBase

DOCK3 interaction

STRING

DOCK3 Proteomic

PRIDE

DOCK3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

DOCK3 Organism specific

CTD

MGI

DOCK3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

DOCK3 Gene expression

Bgee

ArrayExpress

Genevestigator

DOCK3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY