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Mouse Dedicator cytokinesis protein 3 (aa 1-2027 )

Moca Swiss Prot#

Q8CIQ7

Moca Protein names

Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)

Moca Gene names

Dock3 Moca

Organism

Mus musculus (Mouse)

Moca Entry name

DOCK3_MOUSE

Moca Codon optimized cDNA(gene) Clone

Moca Cat #

RPY2683

Tag

Moca contains A 6x histidine tag

Moca Formulation

Liquid

Moca Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Moca Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Moca Protein

Moca Cat #

PY2683

Moca Source

recombinant

Moca Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Moca Purity

>90%, as determined by SDS-PAGE under reducing conditions

Moca Activity

N/A

Tag

Moca Contains A 6x histidine tag

Moca Formulation

Liquid

Moca Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Moca family

DOCK family

Moca Subcellular locations

Cytoplasm.

Moca FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors.

Moca Sequence

DDBJ

EMBL

GenBank

Moca 3D structure

ModBase

Moca interaction

STRING

Moca Proteomic

PRIDE

Moca Genome annotation

Ensembl

GeneID

KEGG

UCSC

Moca Organism specific

CTD

MGI

Moca Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Moca Gene expression

Bgee

ArrayExpress

Genevestigator

Moca Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY