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Mouse Girdin (aa 1-1873 )

Grdn Swiss Prot#

Q5SNZ0

Grdn Protein names

Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)

Grdn Gene names

Ccdc88a Grdn Kiaa1212

Organism

Mus musculus (Mouse)

Grdn Entry name

GRDN_MOUSE

Grdn Codon optimized cDNA(gene) Clone

Grdn Cat #

RPY2645

Tag

Grdn contains A 6x histidine tag

Grdn Formulation

Liquid

Grdn Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Grdn Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Grdn Protein

Grdn Cat #

PY2645

Grdn Source

recombinant

Grdn Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Grdn Purity

>90%, as determined by SDS-PAGE under reducing conditions

Grdn Activity

N/A

Tag

Grdn Contains A 6x histidine tag

Grdn Formulation

Liquid

Grdn Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Grdn family

CCDC88 family

Grdn Subcellular locations

Membrane. Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Cell projection > lamellipodium.

Grdn FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation.

Grdn Sequence

DDBJ

EMBL

GenBank

Grdn 3D structure

ModBase

Grdn interaction

STRING

Grdn Proteomic

PRIDE

Grdn Genome annotation

Ensembl

GeneID

KEGG

UCSC

Grdn Organism specific

CTD

MGI

Grdn Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Grdn Gene expression

Bgee

ArrayExpress

Genevestigator

Grdn Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY