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Human Girdin (aa 1-1871 )

APE Swiss Prot#

Q3V6T2

APE Protein names

Girdin (Akt phosphorylation enhancer) (APE) (Coiled-coil domain-containing protein 88A) (G alpha-interacting vesicle-associated protein) (GIV) (Girders of actin filament) (Hook-related protein 1) (HkRP1)

APE Gene names

CCDC88A APE GRDN KIAA1212

Organism

Homo sapiens (Human)

APE Entry name

GRDN_HUMAN

APE Codon optimized cDNA(gene) Clone

APE Cat #

RPY2644

Tag

APE contains A 6x histidine tag

APE Formulation

Liquid

APE Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

APE Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant APE Protein

APE Cat #

PY2644

APE Source

recombinant

APE Applications

Western Blot, SDS-Page or may be used for other applications determined by user

APE Purity

>90%, as determined by SDS-PAGE under reducing conditions

APE Activity

N/A

Tag

APE Contains A 6x histidine tag

APE Formulation

Liquid

APE Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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APE family

CCDC88 family

APE Subcellular locations

Membrane. Cell membrane. Cytoplasm > cytosol. Cytoplasmic vesicle. Cell projection > lamellipodium.

APE FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

APE Sequence

DDBJ

EMBL

GenBank

APE 3D structure

ModBase

APE interaction

STRING

APE Proteomic

PRIDE

APE Genome annotation

Ensembl

GeneID

KEGG

UCSC

APE Organism specific

CTD

MGI

APE Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

APE Gene expression

Bgee

ArrayExpress

Genevestigator

APE Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY