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Human SH3 multiple ankyrin repeat domains protein 3 (aa 1-1741 )

SHANK3 Swiss Prot#

Q9BYB0

SHANK3 Protein names

SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)

SHANK3 Gene names

SHANK3 KIAA1650 PSAP2

Organism

Homo sapiens (Human)

SHANK3 Entry name

SHAN3_HUMAN

SHANK3 Codon optimized cDNA(gene) Clone

SHANK3 Cat #

RPY2609

Tag

SHANK3 contains A 6x histidine tag

SHANK3 Formulation

Liquid

SHANK3 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

SHANK3 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant SHANK3 Protein

SHANK3 Cat #

PY2609

SHANK3 Source

recombinant

SHANK3 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

SHANK3 Purity

>90%, as determined by SDS-PAGE under reducing conditions

SHANK3 Activity

N/A

Tag

SHANK3 Contains A 6x histidine tag

SHANK3 Formulation

Liquid

SHANK3 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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SHANK3 family

-

SHANK3 Subcellular locations

Cytoplasm. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density.

SHANK3 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

SHANK3 Sequence

DDBJ

EMBL

GenBank

SHANK3 3D structure

ModBase

SHANK3 interaction

STRING

SHANK3 Proteomic

PRIDE

SHANK3 Genome annotation

Ensembl

GeneID

KEGG

UCSC

SHANK3 Organism specific

CTD

MGI

SHANK3 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

SHANK3 Gene expression

Bgee

ArrayExpress

Genevestigator

SHANK3 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY