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Human Rapamycin-insensitive companion mTOR (aa 1-1708 )

RICTOR Swiss Prot#

Q6R327

RICTOR Protein names

Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)

RICTOR Gene names

RICTOR KIAA1999

Organism

Homo sapiens (Human)

RICTOR Entry name

RICTR_HUMAN

RICTOR Codon optimized cDNA(gene) Clone

RICTOR Cat #

RPY2598

Tag

RICTOR contains A 6x histidine tag

RICTOR Formulation

Liquid

RICTOR Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

RICTOR Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant RICTOR Protein

RICTOR Cat #

PY2598

RICTOR Source

recombinant

RICTOR Applications

Western Blot, SDS-Page or may be used for other applications determined by user

RICTOR Purity

>90%, as determined by SDS-PAGE under reducing conditions

RICTOR Activity

N/A

Tag

RICTOR Contains A 6x histidine tag

RICTOR Formulation

Liquid

RICTOR Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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RICTOR family

Pianissimo family

RICTOR Subcellular locations

-

RICTOR FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

RICTOR Sequence

DDBJ

EMBL

GenBank

RICTOR 3D structure

ModBase

RICTOR interaction

STRING

RICTOR Proteomic

PRIDE

RICTOR Genome annotation

Ensembl

GeneID

KEGG

UCSC

RICTOR Organism specific

CTD

MGI

RICTOR Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

RICTOR Gene expression

Bgee

ArrayExpress

Genevestigator

RICTOR Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY