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Human 5'-3' exoribonuclease 1 (aa 1-1706 )

XRN1 Swiss Prot#

Q8IZH2

XRN1 Protein names

5'-3' exoribonuclease 1 (EC 3.1.11.-) (Strand-exchange protein 1 homolog)

XRN1 Gene names

XRN1 SEP1

Organism

Homo sapiens (Human)

XRN1 Entry name

XRN1_HUMAN

XRN1 Codon optimized cDNA(gene) Clone

XRN1 Cat #

RPY2597

Tag

XRN1 contains A 6x histidine tag

XRN1 Formulation

Liquid

XRN1 Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

XRN1 Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant XRN1 Protein

XRN1 Cat #

PY2597

XRN1 Source

recombinant

XRN1 Applications

Western Blot, SDS-Page or may be used for other applications determined by user

XRN1 Purity

>90%, as determined by SDS-PAGE under reducing conditions

XRN1 Activity

N/A

Tag

XRN1 Contains A 6x histidine tag

XRN1 Formulation

Liquid

XRN1 Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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XRN1 family

5'-3' exonuclease family

XRN1 Subcellular locations

Cytoplasm.

XRN1 FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS).

XRN1 Sequence

DDBJ

EMBL

GenBank

XRN1 3D structure

ModBase

XRN1 interaction

STRING

XRN1 Proteomic

PRIDE

XRN1 Genome annotation

Ensembl

GeneID

KEGG

UCSC

XRN1 Organism specific

CTD

MGI

XRN1 Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

XRN1 Gene expression

Bgee

ArrayExpress

Genevestigator

XRN1 Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY