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Mouse Rho-guanine nucleotide exchange factor (aa 1-1693 )

Rgnef Swiss Prot#

P97433

Rgnef Protein names

Rho-guanine nucleotide exchange factor (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho-interacting protein 2)

Rgnef Gene names

Rgnef Kiaa1998 Rhoip2 Rip2

Organism

Mus musculus (Mouse)

Rgnef Entry name

RGNEF_MOUSE

Rgnef Codon optimized cDNA(gene) Clone

Rgnef Cat #

RPY2591

Tag

Rgnef contains A 6x histidine tag

Rgnef Formulation

Liquid

Rgnef Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Rgnef Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Rgnef Protein

Rgnef Cat #

PY2591

Rgnef Source

recombinant

Rgnef Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Rgnef Purity

>90%, as determined by SDS-PAGE under reducing conditions

Rgnef Activity

N/A

Tag

Rgnef Contains A 6x histidine tag

Rgnef Formulation

Liquid

Rgnef Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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Rgnef family

-

Rgnef Subcellular locations

Cytoplasm. Cell membrane.

Rgnef FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis.

Rgnef Sequence

DDBJ

EMBL

GenBank

Rgnef 3D structure

ModBase

Rgnef interaction

STRING

Rgnef Proteomic

PRIDE

Rgnef Genome annotation

Ensembl

GeneID

KEGG

UCSC

Rgnef Organism specific

CTD

MGI

Rgnef Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Rgnef Gene expression

Bgee

ArrayExpress

Genevestigator

Rgnef Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY