All rights reserved

Bio-Magnetic Purification ......   A Powerful Tool for Life Science Research Affinity Magnetic Beads >>> Amine >>                 Aldehyde >>                  Carboxy >>    CDI >>                      DVS >>                          DADPA  >>     Epoxy  >>                 Hydrazide >>                 Hyrdoxy >>     Iodoacetyl >>           NHS >>                         Sulghydry >> Tosyl >>                   Thiol >>                         Silica >> EDTA >>                   IDA >>                      Streptavidin  >> Monomer Avidin >>          Reversed-Phase Magnetic Beads >>> C4 >>                          C8 >>                       C18 >>   Cyanopropyl >>          Phenyl >>                 Dipheny >> Ion Exchange Magnetic Beads >>> DEAE >>                   PSA >>                  SAX >> WCX >>                    SCX >>           Hydroxyapatite  >> Antibody Purification & IP >>> Protein A >>           Protein G >>        Protein A/G >> Protein L >> Recombinant Protein Purification >>> Ni+ Charged Beads >>    Co + Charged Beads >> GST >> DNA & RNA Purification >>> Plant/Animal >>         Bacteria >>             Blood >> Saliva >>                   Stool >>                  Food >> mRNA >>                    PCR >>                   Soil >> Endotoxin Removal Magnetic Beads >>>   Abundant Protein Removal >>> HSA  Removal >>                                    IgG  Removal >> Cell Isolation >>> Bacteria >>                                              Viurs >> More Application >>

Home BioMagnetic Beads Recombinant Protein & Codon Optimized cDNA Service Order Contact Us New Products

For cDNA or Recombinant Protein Search ( Input   Gene name, or Protein Name, or Swiss -prot Accession Number Bioclone Distributor >>>

Email: info@bioclone.us ;  order@bioclone.us

More Than 20,000   Recombinant Protein & cDNA(gene) Virus Antigen  >>> Bacterial Antigen >>> Parasite Antigen  >>> Cell Surface CD Marker >> Cytokines >>> Kinase  >>> Transduction >>> Transcription Factor >>> Common Disease-related Proteins >>> Phosphatase >>> Cancer >>> Drug  metabolism >>> Neuroscience >>> G protein coupled receptors   >>> Stem cell >> Kinase >>> Disease >.>> Toxin & Allergen >>> Cytoskeleton >>

Mouse Nischarin (aa 1-1593 )

Nisch Swiss Prot#

Q80TM9

Nisch Protein names

Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor I-1-like protein) (Imidazoline-1 receptor) (I1R)

Nisch Gene names

Nisch Kiaa0975

Organism

Mus musculus (Mouse)

Nisch Entry name

NISCH_MOUSE

Nisch Codon optimized cDNA(gene) Clone

Nisch Cat #

RPY2568

Tag

Nisch contains A 6x histidine tag

Nisch Formulation

Liquid

Nisch Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Nisch Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant Nisch Protein

Nisch Cat #

PY2568

Nisch Source

recombinant

Nisch Applications

Western Blot, SDS-Page or may be used for other applications determined by user

Nisch Purity

>90%, as determined by SDS-PAGE under reducing conditions

Nisch Activity

N/A

Tag

Nisch Contains A 6x histidine tag

Nisch Formulation

Liquid

Nisch Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

Place Order for Recombinant Nisch Products

For pricing and availability Click Here >>>

Nisch family

-

Nisch Subcellular locations

Cell membrane. Cytoplasm. Early endosome. Recycling endosome.

Nisch FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis (By similarity). Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3 (By similarity). When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures (By similarity).

Nisch Sequence

DDBJ

EMBL

GenBank

Nisch 3D structure

ModBase

Nisch interaction

STRING

Nisch Proteomic

PRIDE

Nisch Genome annotation

Ensembl

GeneID

KEGG

UCSC

Nisch Organism specific

CTD

MGI

Nisch Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

Nisch Gene expression

Bgee

ArrayExpress

Genevestigator

Nisch Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY