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Human Probable global transcription activator SNF2L2 (aa 1-1590 )

BAF190B Swiss Prot#

P51531

BAF190B Protein names

Probable global transcription activator SNF2L2 (EC 3.6.4.-) (ATP-dependent helicase SMARCA2) (BRG1-associated factor 190B) (BAF190B) (Protein brahma homolog) (hBRM) (SNF2-alpha) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2)

BAF190B Gene names

SMARCA2 BAF190B BRM SNF2A SNF2L2

Organism

Homo sapiens (Human)

BAF190B Entry name

SMCA2_HUMAN

BAF190B Codon optimized cDNA(gene) Clone

BAF190B Cat #

RPY2565

Tag

BAF190B contains A 6x histidine tag

BAF190B Formulation

Liquid

BAF190B Storage

Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

BAF190B Applications

Applications: 1. Codon-optimized cDNA(gene) sequence designed for protein production in both E.coli and Mammalian cell. The cDNA(gene) has been cloned into E.coli expression vector with 6x Histidine tag.2. May be used as RNAi assistance to restore the loss-of-function.

Recombinant BAF190B Protein

BAF190B Cat #

PY2565

BAF190B Source

recombinant

BAF190B Applications

Western Blot, SDS-Page or may be used for other applications determined by user

BAF190B Purity

>90%, as determined by SDS-PAGE under reducing conditions

BAF190B Activity

N/A

Tag

BAF190B Contains A 6x histidine tag

BAF190B Formulation

Liquid

BAF190B Storage

;. Storage at -20℃ to −80℃ Upon receipt. Avoid repeated freeze-thaw cycles.

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BAF190B family

SNF2/RAD54 helicase family

BAF190B Subcellular locations

Nucleus.

BAF190B FUNCTION According to UniProtKB Swiss Prot

FUNCTION: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

BAF190B Sequence

DDBJ

EMBL

GenBank

BAF190B 3D structure

ModBase

BAF190B interaction

STRING

BAF190B Proteomic

PRIDE

BAF190B Genome annotation

Ensembl

GeneID

KEGG

UCSC

BAF190B Organism specific

CTD

MGI

BAF190B Phylogenomics

eggNOG

GeneTree

HOGENOM

HOVERGEN

InParanoid

OrthoDB

PhylomeDB

OMA

BAF190B Gene expression

Bgee

ArrayExpress

Genevestigator

BAF190B Family and domain

InterPro

PROSITE

ProtoNet

FOR in vitro RESEARCH USE ONLY